A Guide to Timing and Critical Periods
Related Key Concepts

Children’s biological sensitivity to experiences and exposures in their developmental environment changes as they grow, as part of a dynamic process. Developing biological systems are typically most sensitive during the prenatal period, with young children being more biologically sensitive than adolescents, who are more sensitive to most exposures than many adults. The timing of young children’s experiences and exposures interacts with their gene expression, shaping outcomes well into adulthood. In other words, it’s not just what children encounter in their environment, but when they encounter it that really matters, all of which interacts with how their genes are expressed, in powerfully connected ways.
This dynamic interactive process is responsive to both positive and negative influences, underscoring the importance of providing safe, supporting developmental environments in our children’s earliest years. Explore the resources in this guide to learn more.
Resources in This Guide
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Early Experiences Can Alter Gene Expression and Affect Long-Term Development
Topics: Brain Architecture
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Health and Learning Are Deeply Interconnected in the Body: An Action Guide for Policymakers
Topics: Toxic Stress
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Related Resource Guides
Place Matters: The Environment We Create Shapes the Foundations of Healthy Development
Topics: Developmental Environments
Languages: English, Portuguese, Spanish
Place Matters: What Surrounds Us Shapes Us
Topics: Brain Architecture, Lifelong Health and Wellbeing, Racism
Connecting the Brain to the Rest of the Body: Early Childhood Development and Lifelong Health Are Deeply Intertwined
Topics: Lifelong Health and Wellbeing, Policy Insights
Connecting the Brain to the Rest of the Body: Early Childhood Development and Lifelong Health Are Deeply Intertwined
Topics: Lifelong Health and Wellbeing, Policy Insights
What Is Inflammation? And Why Does it Matter for Child Development?
Topics: Lifelong Health and Wellbeing, Toxic Stress
How Early Childhood Experiences Affect Lifelong Health and Learning
Topics: Lifelong Health and Wellbeing
Languages: English, Spanish
Three Core Concepts in Early Development
Topics: Brain Architecture, Serve and Return, Toxic Stress
Science X Design: Three Principles to Improve Outcomes for Children
Topics: Developmental Environments