Center Director Jack P. Shonkoff discusses the impact of early childhood toxic stress [1] on adult health in the January 23 EdCast, a weekly podcast interview conducted by Matthew Weber at the Harvard Graduate School of Education. In the 14-minute interview, Shonkoff addresses the recent American Academy of Pediatrics policy statement on toxic stress, emphasizing the need for a new generation of interventions that not only identify risk factors but also build protection against their physiological consequences.